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Glutamine is first deamidated to glutamate, in an irreversible reaction catalysed by the enzyme GLS

Carl and Gerty Cori: a collaboration that changed the face of biochemistry

Patients received once-weekly Mounjaro 5 mg, 10 mg, or 15 mg, or placebo

In various cancer models, PRODH has been described as a context-dependent tumor suppressor or promoter, depending on the metabolic state and microenvironment of the cell 63

Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs