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Safety was consistent with the GLP-1 class, with GI adverse events as the predominant findings

Further, SSRIs/SNRIs have a narrow dynamic range , i.e., even at low label doses SSRIs/SNRIs approach saturation occupancy of the SERT (44) , consistent with that SSRI or SNRI dose-increases yield limited added antidepressant efficacy

As a result, the enzyme activity decreases almost by forty percent