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Lipoic acid prevented NOX-induced superoxide production in a rat model of cerebral ischemia and limited infarct volume and neurological deficiencies through upregulating the insulin-phosphatidylinositide-3 kinase (PI3K)-protein kinase B (PKB/Akt) signaling pathway (40)

However, taking collectively the literature produced so far in this field, we can argue that there is substantial evidence indicating that maternal impairments in folate metabolism could favor at least certain errors leading to chromosome 21 malsegragation

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