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Dr Manuel notes that increased body weight inhibits ovulation through several mechanisms, such as disruption of the hypothalamic-pituitary-ovarian (HPO) axis, insulin resistance, altered sex steroid metabolism, and direct effects on oocyte (egg) and endometrial (uterine lining) quality. Weight loss from GLP-1s can help reverse these abnormalities, Dr Manuel says

Should You Stop Taking GLP-1 Drugs Like Ozempic if You Experience Vision Loss

10.1073/pnas.1218051109 67 KleinS.SheardN

Embo J 2019, 38