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10.1089/ars.2009.2634 Antioxid

GLP-1 receptor agonists such as Saxenda and Wegovy work, with clinical trial evidence behind them roughly 6% and 16% body weight reduction respectively over 68-week trials

2 The immunotherapeutic landscape of osteosarcoma: challenges and resistance mechanisms 2.1 The immunosuppressive TME The osteosarcoma TME is a complex ecosystem comprising malignant cells, stromal cells, immune infiltrates, and ECM components embedded within a mineralized bone scaffold ( TAMs represent the most abundant immune cell population within the osteosarcoma TME, often accounting for over 50% of infiltrating immune cells (30)