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UV radiation is non-ionizing and does not penetrate the skin but can cause DNA damage and generate ROS [78]
Interestingly, it also upregulated NLRP3 expression, possibly due to its role in enhancing autophagy (Wang et al., 2023c)
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Highest levels of Ada are found in cells of the lymphoid system, explaining why ADA deficiency causes SCID, and why ADA is a common target for leukemia chemotherapies
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