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Missouri Medicine, 115(4), 380387
122,123 The miRNA drug MRG-201 (Remlarsen), developed by Viridian Therapeutics (formerly known as miRagen Therapeutics), simulates microRNA-29b to reverse regulate fibrosis, thus inhibiting fibrous proliferation in skin wounds
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Han, Q., Robinson, H
On paper that sounds like a contradiction, and at high doses it would be
Here is my breakdown of what is actually happening at the molecular level from: 1, Cell viability assays 2, NanoBRET assay 3, ELISA ternary complex assay 4, Caspase 3/7 Apoptosis assay Phase 1: The True RIPTAC Effect (#Low Dose) In the low nanomolar range, the molecule does exactly what it was designed to do
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