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It is usually a small, well-chosen combination, often built around metformin if eGFR allows, layered with an SGLT2 inhibitor and possibly a GLP-1 receptor agonist, with insulin reserved for when those options are not enough
Recent systematic reviews and meta-analyses consistently demonstrate that weight regain after GLP-1RA discontinuation is substantial and follows a characteristic trajectory, with a large proportion occurring during the early post-cessation period
You will never start at the highest dose
If you're currently covered, you may receive notice of formulary changes before renewal
We discuss its safety & efficacy
thus, the choice of the dose will likely depend on metabolic targets [22]
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