Negative side effects typically improved over time, with many participants having no or minimal side effects at 1216 weeks
By contrast, in the intestine, the primary function of PGC-1 is to maintain mitochondrial function and intestinal epithelial homeostasis [60]
Initial shedding often discourages new users of either compound
Figure 1: Changes in body weight from baseline to the end of treatment at week 26 associated with the trial product estimand, in the randomly assigned treatment groups administered either 0.3 mg of cagrilintide, 0.6 mg of cagrilintide, 1.2 mg of cagrilintide, 2.5 mg of cagrilintide, 4.5 mg of cagrilintide, 3.0 mg of liraglutide, or a placebo
Conklin 2004a
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