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Treatment of Stage III Melanoma That Cannot Be Removed By Surgery, Stage IV Melanoma, and Recurrent Melanoma Treatment of stage III melanoma that cannot be removed by surgery, stage IV melanoma, and recurrent melanoma may include: immunotherapy with pembrolizumab, nivolumab, ipilimumab, interleukin-2 (IL-2), nivolumab and relatimab, or atezolizumab, given alone or in combination targeted therapy with dabrafenib, trametinib, vemurafenib, cobimetinib, encorafenib, binimetinib, given alone or in combination oncolytic virus therapy (talimogene laherparepvec) injected into the tumor palliative therapy to relieve symptoms and improve the quality of life: chemotherapy surgery to remove lymph nodes or tumors in the lung, digestive tract, bone, or brain radiation therapy to the brain, spinal cord, or bone Learn more about these treatments in the Treatment Option Overview