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In 2025, a study by scientists at Nagoya University in Japan showed that luteolin, a naturally occurring antioxidant found in vegetables such as celery, broccoli, carrots, onions, and peppers, had completely reversed greying in mice

The tretinoin in GHK-Cu/Estriol/Niacinamide/Tretinoin may cause a transient increase in irritation

The gradual escalation protocol remained essential for minimizing adverse events

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