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Due to the complicating factor of a shot and the extra cost, it seems the best route for most people is to focus on getting adequate B vitamins from food, and supplement as necessary.

Even using this strategy some patients (minority) do have issues with sleep for the first 1-2 days after each injection

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Skin and Collagen The most consistent outcome at the doses used in our Miami-area protocol is improved skin texture

Diagnosing B12 deficiency is not easy

Sakakeeny et al., Plasma Pyridoxal-5-Phosphate Is Inversely Associated with Systemic Markers of Inflammation in a Population of U.S