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Cardiovascular Safety Studies With DPP-4 Inhibitors The Clinical Guidance for Pharmaceutical IndustryDiabetes MellitusEvaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes established by the FDA in 2008 as a consequence of adverse safety signals of rosiglitazone has set up the requirement for novel diabetes medications to prove cardiovascular safety of these substances in comparison to standard therapy under glycaemic equipoise
Field Methods, 18 (1), 5982
Concurrent medications : Taking other drugs that affect gastric motility or cause nausea may compound the risk
women, in particular, lose 3-5% of their muscle mass per decade starting in their 30s, with that loss only accelerating after menopause
The STEP 1 trial reported an average body-weight reduction of 14.9% with branded injectable semaglutide 2.4 mg over 68 weeks
In GERD, the stomach contents flow back into the esophagus, which is the food pipe, causing an unpleasant burning sensation in the chest or throat
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