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Bidirectional regulatory contradiction: METTL3 simultaneously mediates the m 6 A modification of the 5UTR of dCK mRNA, promotes nuclear export and translation through YTHDC1, and enhances gemcitabine activation, while FTO demethylates dCK, reducing its stability, forming a balanced antagonism that promotes drug resistance/sensitization
doi: 10.1007/s13300-021-01113-y 124 SfairopoulosDLiatisSTigasSLiberopoulosE
J Intercult Ethnopharmacol
Bibcode:2019NatSR...9.9280S
Ibrahim D, Froberg B, Wolf A, Rusyniak DE
In vivo , the administration of Lip-1 enhanced the viability and ferroptotic resistance of retinoblastoma cells, which, in turn, exacerbated the tumorigenesis and invasion of retinoblastoma in murine xenograft models (129)
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