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Human trials of GLP-1 medications in women with PCOS have found (2): Ovulation rates of 86% in women taking GLP-1s alongside metformin - compared to 29% on metformin alone, a threefold improvement 62% of women on GLP-1s had more regular menstrual cycles, versus 28% on placebo Significant reductions in testosterone levels These are meaningful numbers for a condition where restoring ovulation and cycle regularity remains one of the challenges

The binding-induced conformational changes may facilitate the activation of G-proteins, which are signaling proteins hypothesized to be found on the intracellular side of the GHRH receptor

This matches a broader finding that CVS plans technically cover Wegovy in just 18% of their employer-sponsored formularies (2026 data) ( [4] )

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