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Study B The efficacy of TRESIBA was evaluated in a 26 week randomized, open label, multicenter trial in 455 patients with type 1 diabetes mellitus (Study B)

17) Eye Health Glaucoma and cataracts can gradually lead to blindness

Translationally, our model parallels clinical hyperthermia in varicocele (local heat elevation), occupational exposure (e.g., bakers/welders with prolonged scrotal warming), cryptorchidism (undescended testes overheating), and febrile illnesses (systemic temperature spikes impairing spermatogenesis), all driven by oxidative stress [9,10,11,12, 64, 66]

The closest pipeline candidates are orforglipron, the first non-peptide oral GLP-1 from Eli Lilly, with an FDA decision anticipated in 2026, and retatrutide, a triple GLP-1/GIP/glucagon agonist in phase 3

GLP-1s can be used alongside Nutrafol HGNs and are not expected to impact the performance of Nutrafol HGNs or the GLP-1s