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This review systematically delineates LONP1s biological landscape from the aspects of discovery, structure, and function, while critically integrating emerging evidence of its pathophysiological duality across various human disease contexts

[3] [4] While human evidence for direct dopamine modulation is more limited, the clinical effect translates into patients reporting that food seems less appealing, cravings diminish, and the mental space occupied by food-related thoughts decreases substantially

Dirkx E, Schwenk RW, Coumans WA, Hoebers N, Angin Y, Viollet B, Bonen A, van Eys GJ, Glatz JF, Luiken JJ (2012) Protein kinase D1 is essential for contraction-induced glucose uptake but is not involved in fatty acid uptake into cardiomyocytes

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GLP-1 is a hormone your body makes naturally, one of several that helps regulate your appetite

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