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Although leg cramps are not listed as an official adverse effect in FDA prescribing information, understanding the potential indirect mechanismsincluding dehydration, electrolyte imbalances, and nutritional changescan help patients and clinicians address this symptom effectively while continuing therapy

When to seek medical care A person should seek medical advice if they are considering any GLP-1-related product for weight loss or blood sugar control, especially if they have diabetes, prediabetes, obesity, high blood pressure, heart disease, kidney disease, or take regular medications

as an oral communication at the 51st Annual Meeting of the European Association for the Study of Diabetes, Stockholm, Sweden, 1418 September 2015

20 If any of these contraindications are suspected or confirmed, a hepatologist should be consulted before starting or continuing resmetirom

Ensure all training is documented to meet compliance standards

Published literature varies widely on dosage regimens, with an emphasis on the importance of gradual dose selection under the direct support and monitoring of a medical doctor to assess clinical tolerance and individual response assessment