Whilst there is movement to design cannabanoid-1 receptor antagonists that are less hydrophobic to reduce blood-brain barrier penetration and therefore psychiatric side effects [105], we are not aware of any ongoing clinical trials yet
Furthermore, the results from d 14 pi must be interpreted with caution due to the discrepancy in sample size
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However, systemic administration of lactate oxidase carries the risk of off-target H2O2 toxicity, underscoring the need for tumor-specific delivery systems to improve safety and therapeutic outcomes