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Importantly, patients using transdermal medications should avoid exposing the patch to external heat sources such as heating pads, electric blankets, hot tubs, saunas, or prolonged direct sunlight, as heat can increase drug absorption and potentially cause overdose

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Emerging evidence suggests that DPP-4 inhibitor use may be associated with an increased risk of bullous pemphigoid, an autoimmune blistering disorder characterized by edematous erythema and tense blisters [13, 31]

IV delivery bypasses digestive limitations entirely

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