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Vegans and "patients with diseases like Crohn's and colitis as well as people with pernicious anemia are also particularly vulnerable to deficiency," added Silverstein

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[26] Individuals with severe liver disease or with a condition called metabolic acidosis are also contraindicated for Lipo-B

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Since Vitamin B12 is primarily found in animal products, vegetarians and vegans are at a higher risk for deficiencies

The synthesis constitutes a formal total synthesis, since the research groups only prepared the known intermediate cobyric acid, whose chemical conversion to vitamin B 12 was previously reported