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GLP-1 stimulates the -cells to produce Insulin, blocks pancreatic -cells' glucagon release via somatostatin (96), slows down gastric emptying (131), improves peripheral glucose tolerance (132), suppresses appetite in the hypothalamus and amygdala (97), increases -cell mass, GSIS, and elicits protection from glucolipotoxicity (133) and apoptosis (134)
The switch is usually made for patient preference (avoiding injections) rather than clinical superiority
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The body adjusts
Several factors may explain why some patients report flu-like symptoms when taking tirzepatide, even though these are not formally recognized adverse effects
The intensity of it shocked me
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