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Immunhistochemical analysis For cFOS analysis, mice were treated s.c

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However, since mevalonate (the product of the HMG-CoA reductase reaction) is required for the synthesis of other important isoprenoid compounds besides cholesterol, long-term treatments carry some risk of toxicity

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One-way ANOVA was used to compare the mean values across multiple groups, followed by Dunnetts test for post hoc multiple comparisons to allowing for a detailed examination of significant differences between different experimental groups