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1 Guidelines, manufacturers, and FDA warnings have erred on the side of caution and recommend careful use of GLP-1 RAs in patients with a history or high risk of pancreatitis
These authors concluded that the proportion of LBM relative to total body mass increased with semaglutide. Similarly, in the SURMOUNT-1 trial which studied tirzepatide, researchers found that participants treated with tirzepatide had a percent reduction in fat mass approximately 3 times greater than the reduction in lean mass, resulting in an overall improvement in body composition. More recently, a viewpoint in JAMA re-grounded the conversation: weight loss in persons with obesity primarily reduces body fat, but also decreases fat free mass (FFM)
Of note is that the observed median time to onset of the psychiatric AEs in our analysis of the FAERS data aligned with common gastrointestinal AEs such as nausea and vomiting, which were the most frequently reported within the first 30 days of GLP-1 RA treatment ( In this extensive pharmacovigilance study, we observed a significant association between GLP-1 RAs and eight distinct categories of psychiatric AEs, namely, nervousness, stress, eating disorder, fear of injection, sleep disorder due to general medical conditioninsomnia type, binge eating, fear of eating, and self-induced vomiting
The steadier signal is the main draw here
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