The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007
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At excess doses, this pathway could theoretically increase circulating free fatty acids, but no published human trial has reported clinically significant dyslipidemia from acute AOD-9604 overexposure
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Progress on skin is gradual
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