Clinical trials confirmed no effect on serum IGF-1, no negative impact on carbohydrate metabolism, and excellent tolerability with safety profile indistinguishable from placebo
In this instance, reducing overall body fat through a calorie deficit may be an effective approach
This number is intended to represent a higher current that can be supplied for a very short period
Until head-to-head trials establish dose equivalencies (if they ever do), the safest approach is to start each compound from its baseline titration schedule
In the phase 3 REDEFINE 1 trial, the combination of cagrilintide and semaglutide yielded a mean 20% reduction in body weight over 68 weeks in adults with overweight or obesity, significantly outperforming placebo and either agent alone
Prescription anti-nausea medications compatible with breastfeeding do exist, and there is no reason to suffer through severe nausea when safe treatments are available