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Phase 3 trials (the TRIUMPH program) are currently underway (Jastreboff et al., NEJM, 2023)
J.LivN.KlumpermanJ.CofferP
Compounded semaglutide may be clinically appropriate for a patient whose medical needs cannot be met by an FDA-approved drug, but the prescribing provider must evaluate that need
Its anti-inflammatory properties and role in cellular energy production make it a theoretically reasonable addition, and some providers include it as standard in their compounding protocols
Considering the advantages of an acidic pH and the physiological environment of the nose, intranasal formulations should ideally have a pH level between 4.5 and 6.5, which is important to avoid adverse effects on the mucosa or the ciliary movement [102]
