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Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
Al-Tabakha MM
T cells isolated from RA patients are distinctly low in succinate, due to repression of the SUCLG2 gene, which brings the TCA to a halt and shifts from the oxidative to the reductive direction
doi:10.3390/nu10111564 [PubMed] 79
The marketing claim that it does not increase hunger traces back to its favourable comparison with GHRP-6 but that comparison was about ACTH and cortisol, not feeding
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