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Disulfidptosis: a new form of programmed cell death

Animal toxicity studies found no lethal dose for BPC-157, an unusual characteristic suggesting a wide safety margin

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On the contrary, BDH2 overexpression has been associated with poor overall survival in cytogenetically normal AML ( LCN2 overexpressing cells might have an increased LPI pool predisposing them to oxidative stress, whereas BDH2 overexpression might prevent cytoplasmatic iron overload

Over time, oxidative stress, genetics, and aging deplete these cells, leading to the familiar loss of pigment