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CORRECTING GLUTATHIONE DEFICIENCY AND MITOCHONDRIAL DYSFUNCTION IN OLDER HUMANS: A RANDOMIZED CLINICAL TRIAL Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study, Effect of Glutathione Infusion on Leg Arterial Circulation, Cutaneous Microcirculation, and Pain-Free Walking Distance in Patients With Peripheral Obstructive Arterial Disease: A Randomized, Double-Blind, Placebo-Controlled Trial
10.1055/s-2007-1014425 334
Key molecular mechanisms include mitochondrial reverse electron transport activation induced by mutant proto-oncogenes KRAS/BRAF [385], oxidative inactivation of DNA repair enzymes leading to mutation accumulation [386], and constitutive activation of NRF2 pathway [387]
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