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Insulin, GLP-1 agonists such as semaglutide, growth-hormone secretagogues, and most peptide drugs work as receptor ligands or hormone analogues: they bind a defined cell-surface receptor and trigger a signaling cascade whose pharmacology has been mapped in exhaustive detail and tested in large registration trials

Those lawmakers are now directing similar queries toward several of the platforms partners

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As of 2025, 31 states plus the District of Columbia have enacted step-therapy override laws that require insurers to waive the step-therapy requirement when a prescriber certifies clinical necessity

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