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If you have digestive conditions like Crohns disease, coeliac disease or IBS, your gut may struggle to absorb B12 effectively regardless of how much you take orally

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Using the safety and feasibility data from these first-inhuman trials demonstrating that intermittent D+Q was well tolerated in 50 subjects (NCT 02874989 and NCT 02848131), combined with the efficacy data in mouse models, we initiated a Phase I study of senolytic therapy in older adults with early-stage symptomatic AD, SToMP-AD (Senolytic Therapy to Modulate the Progression of Alzheimers Disease, NCT04063124) (107)

Exendin-4, the GLP-1 analogue, is better studied, with an estimated half-life of 18-41 minutes for IV administration in rat models (see reference 6)

While convenience may be tempting, it is generally recommended to draw each dose fresh