The exception: in March 2024, the FDA approved a supplemental indication for semaglutide 2.4 mg (Wegovy) to reduce the risk of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke in adults with established cardiovascular disease and either obesity or overweight (SELECT trial, Lincoff et al., New England Journal of Medicine 2023)
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Redox Biol (2017) 11:6139
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The drug causes increased levels of norepinephrine, and dopamine and inhibits a pathway that is responsible for triggering feelings of hunger