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Biological Activities Protein-bound lipoic acid Enzyme cofactor R -lipoic acid is an essential cofactor for several mitochondrial multienzyme complexes that catalyze critical reactions related to the catabolism (breakdown) of amino acids and the production of energy (15)

Cellular Detoxification Pathways The liver and Cellular Detoxification systems rely heavily on glutathione-dependent processes

The degree of inflammation of the colon was graded semiquantitatively from 0 to 11 according to described criteria (Appleyard and Wallace, 1995) taking into consideration (1) loss of mucosal architecture (score 03), (2) cellular infiltration (score 03) (3) muscle thickening (score 03), (4) crypt abscess formation (score 01) and (5) goblet cell depletion (score 01)

Not recommended for pregnant or breastfeeding women, adolescents or people on medication

Methylcobalamin and adenosylcobalamin are native forms of B12, while hydroxycobalamin or cyanocobalamin are not

Rare but serious: severe allergic dermatitis with blisters, intense burning, or facial swelling