semaglutide lowers risk of heart issues regardless of weight loss Ozempic and Mounjaro: Saving Your BEFORE the Scale Moves SELECT Trial

While this mechanism can result in weight loss, it can also lead to gastrointestinal side effects such as: Nausea Diarrhea Vomiting Bloating Abdominal pain Constipation Sulfur burps (foul, rotten-egg-smelling burps) Acid reflux These adverse effects can be worsened if you overeat past the point of feeling full

I think a way to summarize that is a lot of the low hanging fruit has been picked

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Li et al., 2024) and the activation of innate immune cells (kupffer cells) by signals from inflammatory adipokines and endotoxins from the gut (due to gut dysbiosis)

Semaglutide acts on GLP-1 receptors in the hypothalamusthe brain region responsible for regulating hunger and satiety signals