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However, while these mechanistic insights are promising, the translation into robust clinical outcomes remains limited, and current evidence is largely derived from in vitro and animal models (123125)

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In a rat model, carnosine significantly attenuated pulmonary damage, downregulated NF-B activation, and improved overall survival rates, highlighting its protective role in septic lung pathology (Tanaka et al., 2017

It also downregulated pro-inflammatory signaling through inhibition of NF-B, COX-2, and TRPV1, suggesting a dual antioxidant and anti-inflammatory action that supported both mucosal integrity and epithelial regeneration

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