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Knop FK, Aroda VR, do Vale RD, Holst-Hansen T, Laursen PN, et al

recently demonstrated that GLP-1s natriuretic effect, GLP-1-dependent angiotensin II suppression, and high renal GLP-1 extraction all depend specifically and fully on GLP-1 receptor activation

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As of 2022, GLP-1RAs have been recommended as first-line treatments, along with SGLT-2 inhibitors, for patients with T2DM and cardiovascular disease in American Diabetes Associations Standards of Medical Care in Diabetes (248, 249)

Together, you can build a plan that supports your goals while keeping safety and tolerability at the forefront