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The mechanistic and in-vitro evidence is strong and well-replicated
HGH secretagogues stimulate the bodys natural production of growth hormone by activating pituitary receptors
No prospective cohort studies
In the STEP 1 trial extension, participants who stopped semaglutide after 68 weeks regained roughly two-thirds of their prior weight loss within a year, and related cardiometabolic improvements moved back toward baseline
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