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Preclinical studies suggest the presence of these receptors in bone tissue and cells involved in bone remodeling, though this remains an area of ongoing investigation in humans
In microglial cells, CB2R activation through anandamide, an endocannabinoid, has been shown to induce the activation of ERK1/2 and JNK MAPK
They raise blood sugar levels rapidly after eating
Case reports and post-marketing data have documented various cutaneous reactions in patients taking GLP-1 receptor agonists, including urticaria, rash, and pruritus
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