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Chronic Complication Mechanisms: Sustained hyperglycemia damages small vessels (microvascular disease) via multiple mechanisms including AGE accumulation, protein kinase C activation, and hexosamine pathway flux
Impact of GLP-1 Medications GLP-1 medications are getting a lot of attention lately
Yes, and it is routine
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Weekly to monthly
These medications support weight loss, but avoiding side effects like muscle loss and severe constipation requires effort
All of these mutations are pathogenic variants that result in premature termination of protein synthesis, leading to the formation of truncation proteins with no or abnormal functionality
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