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Whether due to medical conditions

It reaches maximum concentration one to three days after taking a dose

Abbreviations Fe: Ferrum g: Gram GFR: Glomerular filtration rate GGT: Gamma-glutamyl transpeptidase GOT: Glutamic oxaloacetic transaminase GP: General practitioner GPT: Glutamic-pyruvic transaminase HIV: Human immunodeficiency virus HVB: Hepatitis B virus HVC: Hepatitis C virus IF: Intrinsic factor g: Microgram MMA: Methylmalonic acid mg: Milligrams ng: Nanograms pg: Picograms

Acknowledgements This study was funded by Eli Lilly and Company

[5] [2] Patients starting GLP-1 therapy should be aware of: Potential mood changes during the adjustment period, particularly if experiencing significant gastrointestinal side effects The importance of continuing existing mental health treatments unless advised otherwise by their healthcare team Realistic expectations regarding weight loss and metabolic improvements, as unrealistic goals can lead to disappointment Healthcare professionals prescribing GLP-1 agonists should: Screen for depression and anxiety at baseline and during follow-up appointments Monitor for mood changes , particularly in patients with pre-existing mental health conditions Ensure coordinated care between diabetes/obesity services and mental health teams when appropriate It is essential to recognise that GLP-1 agonists are not a substitute for evidence-based depression treatments, including psychological therapies and antidepressant medications when indicated

Yang G, Lei Y, Inoue A, Piao L, Hu L, Jiang H, Sasaki T, Wu H, Xu W, Yu C