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Importantly, baseline data revealed a disproportionately high number of individuals with outofrange values for MMA, Hb, and RDW, which shifted closer to reference ranges following the intervention (particularly in the D + S group), highlighting a movement toward physiological restoration rather than mere numerical improvement
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Using sequencing approaches, Parvimonas micra was found to translocate from the subgingival sulcus of the human oral cavity to colorectal adenocarcinoma, likely migrating in a synergistic consortium with other periodontal bacteria ( Klebsiella , Streptococcus , and Veillonella , can endure harsh acidic environments and migrate to the intestine, particularly in individuals with weakened oralgut chemical barriers (bile and gastric acid), such as infants, people with gastrointestinal disease, individuals using proton-pump inhibitors (PPIs), and elderly people (Xu et al., 2025)
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Edwards, Colombo, and Greaves 2002)
