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Diarrhea and constipation are also commonly observed, each potentially affecting ten to fifteen percent of patients, with individual susceptibility varying based on factors such as baseline gastrointestinal function, dietary habits, and concurrent medications

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GLP-1 receptors are expressed throughout the brain, particularly in the hypothalamic arcuate nucleus, the paraventricular nucleus, the area postrema, the nucleus tractus solitarius, and within dopaminergic reward circuitry