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Pediatrics 105, e22

The co-activation of both receptors in retatrutide may therefore reduce appetite through two partially independent central pathways, which could explain why the compounds appetite-suppressing effects exceed what GLP-1R agonism alone achieves

Let me explain why this makes clinical and business sense, what you need to know about doing it safely, and how it fits into the bigger picture of modern psychiatric practice

Slowing the semaglutide dose titration schedule or temporarily reducing the dose can improve tolerability

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