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Tirzepatide Dosing Direct answer: per FDA labeling, tirzepatide starts at 2.5 mg once weekly for 4 weeks (an initiation dose, not a therapeutic dose), then increases by 2.5 mg every 4 weeks as tolerated

Yaghoobi R, Omidian M, Bagherani N

Rarely, people feel mild fatigue as detoxification pathways activate

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