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Preclinical toxicology studies in animals showed no concerning findings with chronic administration, but human long-term data would strengthen confidence in extended protocols

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Thompson JP, Marrs TC

What they did: Isolated human chondrocytes (from osteoarthritis patients and healthy donors) were exposed to AOD-9604 at doses 1 to 1000 nM

Furthermore, the combination of cetuximab and GPNA in gastric cancer cells significantly induced apoptosis and exhibited a more potent inhibitory effect on gastric cancer proliferation in vitro and in vivo than either treatment alone

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