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Metabolic analysis as a driver for discovery, diagnosis, and therapy

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These results suggest that BPC157 was rapidly metabolized into low levels of a variety of small peptide fragments, finally resulting in a single amino acid represented by [ 3 H]proline, which entered the normal amino acid metabolism and excretion pathway in the body

In vitro experiments demonstrated that cancer-associated adipocytes upregulate the hexosamine biosynthetic pathway (HBP), leading to O-GlcNAcylation and stabilization of the YAP protein

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