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Detection indicators: bone density (lumbar spine, hip), bone turnover markers (OC, CTX), bone microstructure (number, thickness, and gaps of bone trabeculae), and skeletal mechanical strength

The experimental evidence base for DSIP is heterogeneous

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This was the approach reported in several key studies with gilthead seabream and European seabass (Schrama et al., 2018

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doi:10.1128/mmbr.41.1.47-99.1977