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221 Observational studies have found a higher incidence of birth defects in babies conceived via assisted reproductive techniques, especially those conceived using intracytoplasmic sperm injection

Lipodystrophyabnormal accumulation or loss of subcutaneous fat at injection sitescan develop with repeated injections in the same location

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Percentages of proliferative (BrdU + ) (n = 6 technical replicates representative of 2 independent experiments) ( a ) and apoptotic (Annexin V + ) (n = 3 technical replicates representative of 3 independent experiments, **p = 0.0042) ( b ) cells were determined

Secondly, there is a lack of uniformity in the efficacy evaluation methods employed across studies

They are typically reserved for short-term, acute relief and should be used sparingly and only as directed by a healthcare professional