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That final 5 mg escalation delivers only about 1 additional percentage point of weight loss while significantly increasing side effect exposure
If adverse effects outweigh benefits, prioritize safety and de-escalate
For this reason, Duloxetine should not be prescribed for patients with substantial alcohol use
Stennis Watson, et al
Considering the potential appetite-reducing effects of GLP-1 RAs, diet-restricted control groups were included for both drugs, ensuring consistent food intake between treatment and control groups, thereby minimizing any dietary bias
In the study, 32 patients between the ages of 34 and 54 and without diabetes were given 1,000 milligrams of Acetyl-L-Carnitine twice daily for 6 months
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